Table 2: Patient characteristics

Outcome

Outcome

Characteristics

All Patients

Normal cognitive function

Learning disabled or mentally handicapped

p-value1

With
epilepsy

Without
epilepsy

p-value1

(n=41)

(n=16)

(n=25)

(n=20)

(n=21)

n (%)

n (%)

n (%)

n (%)

n (%)

Male

26 (63)

9 (56)

17 (68)

0.52

14 (67)

12 (57)

0.52

Side of injury

Left

22 (54)

8 (50)

14 (56)

0.76

9 (45)

13 (62)

0.35

Right

19 (46)

8 (50)

11 (44)

11 (55)

8 (38)

Pregnancy

Normal2

28 (68)

13 (81)

15 (60)

0.19

12 (60)

16 (76)

0.33

Abnormal

13 (32)

3 (19)

10 (40)

8 (40)

5 (24)

Length of gestation

Term (36 weeks)

29 (71)

12 (75)

17 (68)

0.73

15 (75)

14 (67)

0.73

Premature

12 (29)

4 (25)

8 (32)

5 (25)

7 (33)

Delivery

Normal

34 (83)

13 (81)

21 (84)

1

17 (85)

17 (81)

1

Abnormal

7 (17)

3 (19)

4 (16)

3 (15)

4 (19)

Post natal period

Normal

20 (49)

7 (44)

13 (52)

0.75

10 (50)

10 (48)

1

Abnormal

21 (51)

9 (56)

12 (48)

10 (50)

11 (52)

Clinical pattern

Arm dominant

20 (49)

3 (19)

17 (68)

0.003

15 (75)

5 (24)

0.002

Leg dominant

14 (34)

10 (62)

4 (16)

2 (10)

12 (57)

Proportional

7 (17)

3 (19)

4 (16)

3 (15)

4 (19)

Upper limb function

Grade 0-1

20 (49)

5 (31)

15 (60)

0.11

14 (70)

6 (29)

0.01

Grade 2-3

21 (51)

11 (69)

10 (40)

6 (30)

15 (71)

Imaging Findings

Positive cortical grey

23 (56)

5 (31)

18 (72)

0.02

19 (95)

4 (19)

<0.01

Negative cortical grey

18 (44)

11 (69)

7 (28)

1 (5)

17 (81)

Notes: 1 Fisher's exact test for descriptive purposes only. 2 Including twins or triplets.

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Table 3: Potential risk factors for cognitive function and epilepsy

Factor / Outcome

Reference Level

Learning disabled or mentally handicapped
Odds Ratio1 (95% CI)
[p-value]2

Epilepsy
Odds Ratio1 (95% CI)
[p-value]2

Pregnancy

Abnormal

Normal

2.9 (0.7, 12.8) [p=0.08]

2.1 (0.6, 8.2) [p=0.14]

Clinical Pattern

Arm dominant

Leg dominant

14.2 (2.6, 75.8) [p=0.001]

18.0 (3.0, 107.7) [p<0.01]

Arm dominant

Proportional

4.3 (0.6, 29.2) [p=0.07]

4.0 (0.7, 24.4) [p=0.07]

Upper limb function

Grade 0-1

Grade 2-3

3.3 (0.9, 12.4) [p=0.08]

5.0 (1.4, 20.0) [p< 0.01]

Imaging findings

Positive cortical grey

Negative cortical grey

5.7 (1.4, 22.3) [p=0.007]

80.7 (8.5, 767.3) [p< 0.01]

Notes: "CI" stands for confidence interval. 1 Odds ratio was estimated from a logistic regression relating outcome (i.e. abnormal cognitive function or epilepsy) with each of the risk factors. 2 chi-square test of no effect due to each risk factor.

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