Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy and Skin Changes (Poems) Syndrome

     I. Milanov and D.Georgiev

Abstract:   A patient with a three year history of POEMS syndrome-polyneuropathy, hepato-splenomegaly M-protein, skin changes, optic disc edema, peripheral oedema, pleuritis, lymphadenopathy, and osteosclerotic myeloma is described. The patient had a twenty year history of psoriasis and impotence was the first sign of the disease. The pathophysiology of this multisystem disorder is unknown, although the M-protein is essential. No improvement was found after radiation, chemo-therapy and steroid treatment.

Can. J. Neurol. Sci. 1994; 21: 60-63